This reduces blood flow to the heart and increases the risk of heart disease, stroke and heart attack. suzanne66 4 Sep 2011. For many years, doctors have recommended avoiding grapefruit while taking statins, but a study sponsored by the Florida Department of Citrus and published in the "British Journal of Clinical Pharmacology" in 2011 found only an insignificant interaction between grapefruit and Lipitor and no negative effects 3. Our team periodically reviews articles in order to ensure content quality. Here’s what you need to know about diet when you’re on a statin for high cholesterol. lipitor. Good juices for lowering cholesterol: Orange, kiwi and strawberry juice A juice loaded with vitamin C and E is one of the best options for controlling bad cholesterol as well as preventing it. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Regular oranges and orange juice are safe to consume with Lipitor. Research has shown that grapefruit disrupts the metabolism, or breakdown, of many medications, according to an article published in the August 15, 2006 issue of "American Family Physician.". Featured on BlackDoctor There are some drugs on the market that come with a warning that states the patient should not take the medication if they also consume orange or other citrus juices (grapefruit, lemon, etc) because of the possibility of potentially dangerous interactions. Prune juice has long been known to help alleviate constipation. MA. Dr. Savard says avoiding grapefruit juice is important as it can interfere with how the statin metabolizes in the body. On Foods to Avoid when on Statins. Yes - that's fine. Data sources include IBM Watson Micromedex (updated 2 Nov 2020), Cerner Multum™ (updated 2 Nov 2020), ASHP (updated 23 Oct 2020) and others. While researchers continue to explore orange juice's potential, you’ll get a more certain result from buying it fortified with natural substances known to lower cholesterol. Answer this question. Rhabdomyolysis has also occurred rarely, which may be accompanied by acute renal failure secondary to myoglobinuria and may result in death. Greater increases in Cmax (up to 71%) and/or AUC (up to 2.5 fold) have been reported with excessive consumption of grapefruit juice (>=750 mL to 1.2 liters per day). Common Questions and Answers about Lipitor orange juice. https://www.drugs.com/food-interactions/atorvastatin,lipitor.html. Orange Juice Affects Cholesterol . We comply with the HONcode standard for trustworthy health information -. Grapefruit, Pomegranate Juice Not a Good Mix With Statins Pomegranate juice, like grapefruit juice, may pose health risks with drugs. Orange juice contains a variety of nutrients and phytochemicals, such as vitamin C and citrus flavonoids, that may play a role. Grapefruit may reduce the intestinal concentration of an certain enzyme by nearly 50 percent, the authors report. Therapy should be discontinued if creatine kinase is markedly elevated in the absence of strenuous exercise or if myopathy is otherwise suspected or diagnosed. Clinically, high levels of HMG-CoA reductase inhibitory activity in plasma is associated with an increased risk of musculoskeletal toxicity. Available for Android and iOS devices. The citrus fruit pomelo as well as Seville oranges, known as bitter orange, also may interfere with the metabolism of Lipitor, according to MayoClinic.com. In addition, patients should either refrain from the use of oat bran and pectin or, if concurrent use cannot be avoided, to separate the administration times by at least 2 to 4 hours.
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